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Nature Immunology , 24 (3), 452462

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A 2025 study in Neuroscience Letters found that chronic administration of BDNF-stimulating compounds in rodents led to receptor desensitization within 16 weeks, requiring progressively higher doses to maintain effect

Omata, Y., Salvador, G.A., Supasai, S., et al., Decreased zinc availability affects glutathione metabolism in neuronal cells and in the developing brain, Toxicol