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Solvent Residues: Peptides synthesized using improper methods may retain harmful solvents like trifluoroacetic acid (TFA)

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In support of this idea, when holoTC concentrations were subtracted from total vitamin B-12 concentrations, the remaining vitamin B-12, represented by the holohaptocorrin (holoHC) fraction of serum vitamin B-12, was unaffected by the concentration of plasma folate (Figure 8B)

People with Crohns disease, irritable bowel syndrome, gluten enteropathy (celiac disease), or any other disease that cause malabsorption of nutrients