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Acute acrolein overload in the Aldh2*2 KI mice resulted in tissue injury not only in the liver but also in the bone marrow, spleen, and intestines, suggesting a systemic influence of the aldehyde storm

"The data and hypothesis are very intriguing, but much additional investigation is required to determine if this is a real cause-and-effect phenomenon," said Josh Miller, a professor of nutritional sciences at Rutgers University who was not involved with the study

Our model simulations suggest that chronic usage of APAP at recommended therapeutic levels probably does mild liver damage and may be associated with a reduction in GSH levels that compromise antioxidant defense capacity

Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibiting PI3K/AKT pathway