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It can hurt more when you inject cold insulin

Interrupting or postponing treatment with vitamin B12 causes harm, both physically and psychologically

Key Takeaways Location and Method Dictate Your Results : The injection sitebe it your arm, thigh, or buttocksand the technique used directly influence your comfort and how effectively your body absorbs the vitamin B12

[10] Gastrointestinal disturbances-including nausea, loose stools, and a transient fishy body-odor attributable to trimethylamine production from excessive carnitine and choline metabolism-occur in a minority of recipients and are usually self-limiting within 24 to 48 hours after injection

Frequency depends on your goals and the type of shot