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The 8 SNPs showed no association with smoking behavior in an independent dataset of 74,035 participants, ruling out smoking as a confounding pathway through the genetic instrument

[16] [121] Upon leaving the stomach the hydrochloric acid of the chyme is neutralized in the duodenum by bicarbonate, [122] and pancreatic proteases release the vitamin from HC, making it available to be bound by IF, which is a protein secreted by gastric parietal cells in response to the presence of food in the stomach

It is also the cheaper option of the two medicines but must be given more regularly (one per month) which makes it less convenient for most people