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REDEFINE 1 Phase 3 results (2025

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1[J]

Their effects are primarily centered on cellular metabolism and fat breakdown, not neuroendocrine pathways related to hunger

This regulation is bidirectional: the peptide can increase or decrease NO production depending on the pathological context, thereby contributing to vascular protection and inflammation reduction

Phase 2 trial data published in the New England Journal of Medicine (2023) demonstrated significant weight reduction in adults with obesity, and Phase 3 trials are ongoing (ClinicalTrials.gov)