Where reported, values were compared using chi-squared tests for categorical endpoints, T -tests for normally-distributed continuous endpoints, the Wilcoxon signed-rank test for non-normally-distributed continuous endpoints, and Welchs T -test where there was evidence of significant heteroscedasticity
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Moreover, an increase in estrogen and progesterone receptors were obvious in the dermis and epidermis layers of the melasma lesions, respectively

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Recent advances in understanding the role of iron and ROS in cell death offer unexpected surprises and suggest new therapeutic avenues to treat cancer, organ damage and degenerative disease