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In Alzheimer disease specifically, BDNF deficits are most pronounced in the hippocampus, entorhinal cortex, and prefrontal cortex, the regions earliest and hardest hit by the disease

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Therefore Compared to local steroid injection, local autologous PRP injection is more effective in relieving pain and improving the foot and ankle function at mid-term follow-up. In a November 2019 ( 18 ) study, Orthopedic surgeons in the Netherlands found that when they treated patients with PRP and corticosteroid, treatment of patients with chronic plantar fasciitis with PRP seems to reduce pain and increase function more as compared with the effect of corticosteroid injection. Similar findings were published in December 2019 ( 19 ) from Orthopedic surgeons in China who wrote: The use of PRP yields statistically and clinically better long-term functional improvement than that of corticosteroid in the treatment of plantar fasciitis. In November 2019, ( 20 ) doctors reporting on their study findings in the Malaysian orthopaedic journal wrote: Local injection of platelet-rich plasma is an effective treatment option for chronic plantar fasciitis when compared with steroid injection with long lasting beneficial effect. Seventy patients who failed three months of conservative plantar fasciitis care treatment were assessed for improvements following PRP or corticosteroid injections in a July 2023 study ( 21 )

Sleep and recovery Sleep deprivation undermines weight loss through multiple mechanisms