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Although the overall evidence suggests that at least a subset of patients with ME/CFS exhibit reduced cortisol output, some cohorts show only modest reductions, preserved cortisol output, or context-dependent abnormalities rather than stable hypocortisolism, indicating that HPA-axis dysfunction in ME/CFS is likely heterogeneous and multifactorial rather than a specific or uniform neuroendocrine abnormality (Cleare, 2003

A variety of factors can put someone at risk for a nutrient deficiency, including: Inadequate diet Increased nutrient demands due to pregnancy, breastfeeding, and menstruation Decreased nutrient absorption from GI conditions like celiac and Crohn's disease Genetic mutations (like the MTHFR polymorphism) Lower bioavailability of some nutrients (e.g., zinc and iron) from plant versus animal sources Decreased synthesis of vitamin D from sunlight among individuals with dark-colored skin Common medications that impact nutrient absorption, metabolism, and excretion Aging, which can trigger changes (such as decreased stomach acid) that decrease vitamin D and B12 absorption Now let's explore seven common nutrient deficiencies that can impact metabolic health and the blood tests that check for these deficiencies