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DSIP administration did not significantly affect corticotropin-releasing-hormone (CRH)-stimulated or meal-induced ACTH and cortisol secretion, indicating thatcontrary to stress-protective effects reported in some animal studiesDSIP does not measurably blunt the human cortisol response

GSK-3 inhibition supports neuronal survival and may contribute to P21's antidepressant-like effects observed in animal models

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IV delivery ensures full absorption regardless of gut health or intrinsic factor levels, a real advantage for patients who have not responded to oral supplementation