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Understanding this journey is not merely a pharmacokinetic exercise but is fundamental to explaining the disparate outcomes observed in clinical trials and for designing precision-based interventions

Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands

doi: 10.1210/jc.2017-01736 17 LeoMBartalenaLRotondo DottoreGPiantanidaEPremoliPIonniIet al

-adrenergic blockers are also not recommended as first-line therapy for hypertension because they may be associated with increased incidence of adverse cerebrovascular and cardiovascular outcomes [2]

Another proof of this was that motor fluctuations in PD patients improved after SIBO eradication, hence providing more support of the association between SIBO and motor fluctuations (Lubomski et al., 2020)