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Synapse targets the structural foundation of cognitive function: the density and quality of synaptic connections between neurons

Erdem et al

The combination of BRAF and MEK inhibitors, such as dabrafenib and trametinib, has proven particularly effective, enhancing PFS and OS while minimizing toxicity compared to BRAF inhibition alone (45)

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255,256 In contrast, even selective P13K subtype inhibitors have the risk of immunosuppression and secondary bacterial infections, 251 and reducing the occurrence of side effects will be an important issue (Table 4)