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Table 45 Physical stability for cagrilintide and semaglutide co-formulation with varying HP-B-CD concentrations 1 Result is the mean of 6 replicates 2 MS: molar substitution, corresponds to hydroxy propyls per glucose unit Concluding Remarks The results presented in table 45 show that the physical stability of the cagrilintide and semaglutide co-formulation is dependent upon the concentration of HP-B-CD, with lower concentrations resulting in shorter lag time until fibrillation occurs

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Concerns about potential teratogenicity (birth defects), effects on pregnancy, or safety during lactation have not been adequately studied, so use during pregnancy or breastfeeding is not recommended absent compelling indication and appropriate medical supervision

Different Injection Routes Intranasal peptides (Semax, Selank), IM peptides, and oral peptides should never be combined into a single injection syringe

This idea comes from a smaller study published in The Journal of Clinical and Aesthetic Dermatology