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Therefore a B12 deficiency may lead to decreased serotonin production, which in turn may cause a depressed mood

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A 2025 systematic review (PMC, 36 studies, 1993-2024) found consistent improvement in tendon, ligament, muscle, and bone healing in animal models

The Akkermansia species muciniphila has been shown to alter glucose and lipid metabolism as well as intestinal immunity 86 , to strengthen the integrity of the enterocyte monolayer to possibly improve intestinal barrier integrity 87 , and to improve glucose tolerance and reduce visceral adipose tissue inflammation in mice fed an HFD 88

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