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During OxS condition, Nrf2 is transported from cytoplasm into the nucleus by karyopherins , where SARS-CoV-2 interferes with transfer process and reduces GSH synthesis 594

We next assessed whether transport could be attributed to membrane damage

Lee, Y.-J

45 In vivo administration of GSH has been demonstrated to enhance the activation of cytotoxic T-cells, but depletion of GSH intracellularly inhibited the activation of lymphocytes, increased susceptibilities of human lymphoid cells to radiation, and suppressed cell-mediated cytotoxic functions, suggesting that intracellular GSH can modulate the function of immune cells