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The most studied SH with regards to inflammation, 2,5-dimethoxy-4-iodoamphetamine (DOI), has been shown to profoundly suppresses TNF- mediated inflammation in rodent tissues at picomolar concentrationsequating to a dose in humans at least two orders of magnitude below what is necessary to produce hallucinogenic effects [185, 193, 194]

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Following euthanasia, liver, heart, and pancreas tissues were rapidly excised and fixed in buffered formalin-saline for subsequent histopathological and immunohistochemical analyses

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