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These studies contribute to the broader field of peptide drug development by informing best practices for improving the pharmacokinetic and physicochemical profiles of therapeutic peptides

Note that the metabolic pathway of -MTrp follows [176] the biosynthetic route of serotonin from tryptophan (Trp) [177]

doi: 10.1038/s41401-023-01185-5

Interestingly, despite the presence of superoxide dismutase (SOD) ( k = 2.4 10 9 M 1 s 1 ) 36 , the resulting concentration of H 2 O 2 is significantly smaller than the concentration of superoxide, indicating that the model is able to respond well to a transient increase in ROS, maintaining low H 2 O 2 concentrations