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doi: 10.1371/journal.pone.0104762 115 ZhuMYLinDLiuJMoHY

Excessive pyroptosis leads to rapid rupture of the plasma membrane and the excessive release of proinflammatory cytokines and chemokines, which results in neuroinflammation that triggers a cascade of secondary injuries culminating in neuronal death

Moreover, in fresh samples from patients who underwent neoadjuvant chemotherapy, the GSH/GSSG levels in the resistant group were significantly higher than those in the sensitive group, which is consistent with previous research [28]

After processing, four samples did not reach the 2 10 6 cells, which was used as a threshold number for experiments

Weir HJ, Yao P, Huynh FK, Escoubas CC, Goncalves RL, Burkewitz K, et al