For all gastric helicobacters, the mode of action of the GGT mostly depends on the breakdown of 2 substrates, glutathione (GSH) and glutamine (Gln), both leading to the production of glutamate 8,19,20,21,22
Glutamine and barrier function in cultured caco-2 epithelial cell monolayers
Moreover, HPLC-MS/MS techniques allow for the precise identification and quantification of ROS byproducts, providing detailed information on the types of oxidative damage occurring within the cell
NOX4 is up-regulated following viral infection in lung epithelial cells, and it is responsible for the ROS generation that promotes the nuclear export of viral ribonucleoprotein favoring viral replication [96]
Prospects for treatment of free radical-mediated tissu injury