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In light of these data, we suggest therapies that target energy metabolism and ROS generation to improve kidney function recovery may need to also target the energy and redox derangements observed in the liver

Published, peer-reviewed, placebo-controlled clinical trial data from some of the most rigorous obesity research ever conducted

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2 Methods 2.1 Animals and procedures The animal experimental procedures were approved by the Animal Care and Use Committee of Oujiang Laboratory (SYXK2023-0047, OJLAB22121609), and were carried out in strict accordance with the National Institutes of Health Guidelines for the Use of Laboratory Animals

Several compounds target overlapping or complementary pathways in ways that warrant consideration