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Cardiovasc Res 36:276281 Masaki I, Yonemitsu Y, Yamashita A, Sata S, Tanii M, Komori K, Nakagawa K, Hou X, Nagai Y, Hasegawa M et al (2002) Angiogenic gene therapy for experimental critical limb ischemia: acceleration of limb loss by overexpression of vascular endothelial growth factor 165 but not of fibroblast growth factor-2

You shouldn't use it all and if you're not, there's something wrong there that you're using all of it, and you're getting no spillover back into your bloodstream which gets filtered into your bladder, your urine, which you urinate out

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With oral vitamins it can take days or weeks of daily dosing to build up the same effect