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138 Alternatively, other effects of Ang-(17) appeared to be mediated by AT 1 and AT 2 receptors as they were inhibited by the AT 1 and AT 2 receptor-selective antagonists (Figure 2), 139 although radioligand binding assays suggested that these were low-affinity interactions

For example, when histamine binds to a receptor on endothelial (blood vessel) cells, it causes vascular permeability, resulting in swelling and inflammation

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This can help relieve and prevent future migraines