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No melanoma risk from dermatological effect: PT-141's reduced MC1R activity means it does not produce the sustained melanocyte stimulation associated with Melanotan II's mole-darkening risk profile

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While these responses are adaptive in the short term, prolonged exposure to high cortisol levels and chronic stress can lead to maladaptive outcomes such as immunosuppression, impaired growth, altered behaviour, and oxidative damage, leading to increased disease susceptibility and reduced performance [19, 83]