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Except for FLOW, renal outcomes were evaluated as secondary endpoints, with limited statistical power for definitive conclusions

The half-life and solubility of growth factors, the proper carrier, and the presence of inhibitors need to be taken into consideration when growth factors are used in regenerative strategies [84]

TB-500 is specifically categorized under the S2 Peptide Hormones, Growth Factors, Related Substances, and Mimetics classification, strictly banning its use due to its performance-enhancing effects on tissue regeneration and cellular mobility

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