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Phase IIb study of intranasal glutathione in Parkinson's disease

In WT mice, eNOS RNA levels increased from 6 to 40 h post-PH

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Therefore, in our transcriptomic analysis, special interests were paid to pathways of carbon metabolism, lipid metabolism (glycerophospholipid) and DNA biosynthesis (including cell cycle, DNA replication and purine/pyrimidine metabolism)

This view is consistent with arterio-venous difference studies showing that the brain is a net exporter of free choline, with the rate of choline efflux varying depending on metabolic conditions [70, 79]