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(Both a federal law and a state law set this 21 year minimum-age.) It is illegal to sell, give or furnish tobacco products, vapor products or alternative nicotine products to persons under 21

This paradox has been attributed to several mechanisms, including the lower body weight of smokers, selection bias, survival effects, more intensive clinical management of cardiovascular risk factors in smokers, and the vasodilatory properties of chronic carbon monoxide exposure [12]

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Smokeless tobacco cessation guidelines for health professionals in England