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Methods Ethics declarations All the animal experiments were performed following the Guide for Care and Use of Laboratory Animals, approved by the Animal Experimentation Ethics Committee of China Pharmaceutical University (2022-10-017)

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After removing the surrounding skin and muscles, the right knee joint of the mice was fixed with 4% paraformaldehyde at room temperature for 48 h

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Lonidamine liposomes to enhance photodynamic and photothermal therapy of hepatocellular carcinoma by inhibiting Glycolysis