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First, statins may be able to decrease the expression or the downstream signaling pathways of DAMP and PAMP molecules which would trigger NLRP3 activation

further identified seven tear fluid proteins with significantly altered expression, that had a role in protein repair and clearance system or regulation of the cytoskeleton 20

Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1

PMID 24424182

Behavioral assessments were conducted in the open-field test, while molecular analyses were performed on medial prefrontal cortex tissue