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doi: 10.1111/j.1365-2826.2008.01805.x 8 TalpurHSChandioIBBrohiRDWorkuTRehmanZUBhattaraiDet al

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a fresh receptors output saturates below about 10% surface engagement (Gao 2023), so its near-flat acute signal is a snapshot, not the dose-response

Pal-GHK might inhibit p38 MAPK activation by obstructing the upstream kinases that activate this pathway or interfering with the signaling molecules responsible for its phosphorylation