Current evidence generally supports that these medications can be effective after bariatric procedures, though more research is needed on their long-term outcomes in post-bariatric populations
Excess vitamin B12 is linked to increased cancer growth in certain types of cancer.[ref] Methotrexate, a chemotherapy drug, works by inhibiting the production of methyl folate, thus limiting methionine and DNA synthesis for cell growth
Additional at-risk groups include: Vegans and strict vegetarians , who may have low dietary B12 intake People with autoimmune conditions , including pernicious anaemia or type 1 diabetes Individuals with gastrointestinal conditions such as Crohn's disease or coeliac disease, which impair nutrient absorption People who have undergone bariatric surgery , which can significantly reduce B12 absorption Long-term users of proton pump inhibitors (PPIs) or H2-receptor antagonists , which reduce gastric acid and impair B12 release from food Those with a family history of either pernicious anaemia or diabetes For these groups, simultaneous monitoring of B12 status and glycaemic markers is particularly important to avoid diagnostic errors
Vitamin B12 Medical Encyclopedia [Internet]
Dosing usually runs 200 to 500 micrograms per day, depending on the condition and patient response