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In summary, the core of the nicotine rewarding mechanism lies in its profound impact on dopaminergic transmission in the mesolimbic system, achieved through complex direct and indirect pathways
Propylene glycol is a thinner liquid that provides a stronger throat hit, while vegetable glycerine is thicker and contributes to larger vapour clouds
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Oxford Centre for Evidence-Based Medicine: Levels of Evidence and risk of bias using the Risk of Bias in randomized trials (RoB 2) and Risk of Bias in Non-Randomized Studies of Interventions (ROBINS-I) tools were assessed
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