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In vitro studies using endothelial cell models have demonstrated effects on fibroblast migration rates, endothelial cell tube formation in angiogenesis assays, and cytoprotective mechanisms in cell culture models exposed to oxidative and chemical stressors

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However, gastrointestinal ulceration is still poorly understood, particularly with respect to a general pharmacological/pathophysiological role of various angiogenic growth factors implemented in growth factors wound healing concept

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