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In the presence of differentiation stimuli, abnormal protein folding in the ER activates the unfolded protein response (UPR) signaling, which can be alleviated by global translational attenuation, induction of molecular chaperones, misfolded protein degradation by endoplasmic reticulum-associated degradation (ERAD), and apoptosis (63)

Crankshaw DJ, OBrien YM, Crosby DA, Morrison JJ

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Dado que puede formarse a partir de estos tres aminocidos en el cuerpo( L-Acido Glutmico, L-Cistena, y Glicina), se considera no esencial, porque no tiene que ser obtenido de los alimentos