(PubMed) Eslam M, Newsome PN, Sarin SK, et al
The antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stress. Journal of the International Society of Sports Nutrition
These microbial shifts trigger cascading gutbrain disruption by impairing neurotransmitter signaling, suppressing SCFA production, weakening epithelial barrier integrity, and activating neuroimmune pathways, ultimately resulting in anxiety- and depression-like behaviors in rodent models (Tejkalov et al., 2023
Berberine has been tested in hundreds of studies
Moreover, most studies have assessed individual metabolic parameters in isolation rather than the full MetS spectrum, further limiting causal interpretation of GFD-related metabolic changes