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In rodent tendon and ligament injury models, treated animals showed accelerated tenocyte proliferation and faster collagen-fiber organization versus controls

In PD depression, serotonin transporter and 5-HT1B receptor occupancy was observed to the greatest extent in anterior cingulate, ventral striatum, thalamus, hippocampus, amygdala and brainstem (raphe

Additionally, ubiquitin-specific peptidase 30 (USP30), a deubiquitylating enzyme, has been identified as a negative regulator of this pathway by removing ubiquitin chains

These interactions are theoretical in the context of retatrutide and have not been formally characterised