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Assay: GSH/GSSG in mice stromal cells

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Twenty caffeine-involved signaling pathways were related to NASH, such as chemokine signaling, cytokine-cytokine receptor interaction, phagosome, ECM-receptor interaction, PI3K-AKT signaling, MAPK signaling, Toll-like receptor signaling, NOD-like receptor signaling, and NF-B signaling

Such alterations were depicted as remarkable portal congestion, periportal inflammatory infiltrate, and moderate hepatocyte necrosis (nuclear pyknosis, karyorrhexis, and karyolysis with cytoplasmic eosinophilia), whereas the CTRL group exhibited normal architecture of liver tissue

Artemisinin, a herbal extract from Artemisia annua, possesses anti-inflammatory, antitumor, and antiviral properties (Tu, 2016)