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Epidermal growth factor receptor (EGFR) induces fibroblast proliferation and migration and participates in the renal fibrosis process through downstream signaling pathways such as TGF - 1 / Smad3, STAT3, and ERK1 / 2[53]

Moreover, we excluded patients and controls who suffered from neurodegenerative and neuroinflammatory disorders, such as chronic fatigue syndrome [54], Parkinsons or Alzheimers disease, multiple sclerosis, stroke, or systemic (auto)immune diseases such as diabetes mellitus, psoriasis, rheumatoid arthritis, inflammatory bowel disease and scleroderma, and liver and renal disease

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Lu SC: Regulation of glutathione synthesis

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