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It depends on which genes are varied in the research animals and perhaps what makes up the high-fat diet.[ref] Related article: Diabetes genetic susceptibility Are mast cells at the root of everyones weight problem

RAB22A activates phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K2A) to produce phosphatidylinositol 4-phosphate (PI4P) that recruits ATG12-ATG5-ATG16L1

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