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International Journal of Pharmaceutics 494 , 471478, (2015)

Through these channels, highly concentrated, water-soluble actives such as Glutathione, vitamins, and antioxidants penetrate deeply into the skin, where they stimulate collagen production, enhance cellular renewal, and combat oxidative stress

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In inflamed or diabetic wounds, keratinocytes, fibroblasts, and macrophages overexpress CD44, while the excessive accumulation of ROS generates a redox-imbalanced milieu analogous to tumor oxidative stress