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Description

At the end of the study, all animals were euthanized 24 h after the final injection of thiopental sodium (100 mg/kg) via intraperitoneal injection

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However, robust quantitative translation between administered experimental doses and plausible human internal burdens remains highly uncertain due to variability in exposure assessment assumptions, limited size-resolved data on internal PET burdens in humans (particularly for the nanoscale fraction), and methodological constraints in detecting and characterising sub-micrometre particles in complex biological matrices

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