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Refrigeration before opening is generally not required but is not harmful if done properly

There is an increased risk for diabetic retinopathy complications in patients with a history of diabetic retinopathy at baseline compared to patients without a known history of diabetic retinopathy

If a clinician pooh-poohs a request for a vitamin B12 check because an older person had a recent normal blood count, you can share this research article with the clinician

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The product should be kept in a refrigerator when not in use, and not left at room temperature for prolonged periods, except for drawing up a dose