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The activated beta-3 receptor couples to stimulatory G-proteins (Gs), which activate the enzyme adenylyl cyclase

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Target: 5 mg once daily or 2.5 mg twice daily (BID)

reports research grant support, on behalf of their institution, from Novo Nordisk and advisory/consultancy fees from Boehringer Ingelheim, Eli Lilly & Company, Gila Therapeutics Inc, GLW-01, International Medical Press, Novo Nordisk, Pfizer and ViiV