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Blood samples were collected from dogs administered multiple doses at corresponding time points before the first dosing (0 h), within 6 h after dosing, before the last three doses, and at corresponding time points after the last dosing

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doi: 10.1093/hmg/ddn184 494 HirschfieldGMLiuXXuCLuYXieGLuYet al

Although a barium contrast study (esophagram) should not be used for the diagnosis of GERD, it can be helpful for evaluation of large hiatal hernias and strictures Prolonged Ambulatory Esophageal pH Monitoring Studies Ambulatory pH monitoring of the esophageal lumen, a well- established test, was introduced in the early 1970s