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GLP-1-based compounds work primarily through appetite suppression, and the weight loss they produce includes significant lean mass loss (approximately 40% of total weight lost is lean tissue based on STEP trial data)

Some antioxidants (e.g

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The following relevant parameters were determined where possible: area under the concentration-time curve from time zero to the last time point (AUC 0-last ) or extrapolated to infinity (AUC 0- ), C max concentration in plasma extrapolated to time zero (C 0 ), terminal elimination half-life (t 1/2 ), volume of distribution (Vd), and clearance (CL)