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However, only high-frequency activity induces tissue plasminogen activator secretion, resulting in the conversion of pro- to mature BDNF (13)

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In the physiological state, it is localized in the cell cytosol and is regulated by a variety of protein translational modifications (PTMs) to adapt to different cellular environments, such as phosphorylation, ubiquitination, S-nitrosylation, palmitoylation, and SUMOylation (Jin et al., 2021)

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