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FSP1 as an emerging cancer dependency and therapeutic target FSP1 has progressed from a GPX4-parallel backup system to a tumor-maintenance factor in multiple in vivo settings

So, sleep is an important physiological factor that increases GH release

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Thus, it appears to play a key role in regulating lipid content and hepatic oxidative stress

Moreover, since the inception of this study, multiple metabolic mechanisms promoting drug resistance have been suggested for 5FU treatment, including changes in amino acid metabolism 69,70 , serine and glycine metabolism 71,72,73 and glycolysis 74,75 , corroborated within our study and independently validating our findings