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ROS also promote the overexpression of p53 and its target genes in melanocytes which induce the release of insulin-like growth factor-binding protein 3 and 7 (IGFBP3 and IGFBP7), matrix metalloproteinase-3 (MMP3), interlukin-6 (IL-6), and prostaglandin-endoperoxide synthase 2 (PTGS2)

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In the EPB41L4A-AS1-specific knockout astrocyte cell line U251, A 1-42 addition led to significant impairment in A 1-42 clearance and expression of autophagy-related genes (ARGs)

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