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Knowing the fact that UF is hormone-dependent, which is mainly associated with the estrogen hormone (Marshall et al., 1998), estradiol has been found to contribute to the growth of leiomyoma via the activation of ERK (Nierth-Simpson et al., 2009)

There is also the counteraction of cognitive dysfunction exemplified through the novel object recognition test as a particular negative-like symptom [204,205,206,207] in the schizophrenia model (acute ketamine treatment (3 mg/kg i.p.)) [171]