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Phytochemistry 69, 3848

These findings suggest that administering hepsin can effectively regulate GJ expression in wild-type mice, highlighting its potential as a therapeutic target to protect against APAP-induced hepatotoxicity, potentially in human patients

Genistein, a soy isoflavone that preferentially binds to ER, has been shown to reduce hypoxia-induced hydrogen peroxide (H 2 O 2 ) production, increase Bcl-2 expression, decrease cytochrome c release from mitochondria, and significantly lower apoptosis rates associated with hypoxia (69)