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Reversibility post-cessation : Evidence suggests partial restoration of oral and gut microbiota after smoking cessation (e.g., Neisseria recovery in saliva, Lactobacillaceae increase with modified-risk products), but long-term ecological resilience and its health implications require longitudinal human cohort studies

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Abbreviations BMI: Body Mass Index CDK: Cyclin-dependent kinases CI: Combination index COX-2: Cyclooxygenase 2 DMSO: Dimethyl sulfoxide DNA: Deoxyribonucleic acid DSB: Double strand break DYRK1A: Dual-specificity tyrosine-phosphorylated and regulated kinase 1A EGFR: Epidermal growth factor receptor EMT: Epithelial-to-mesenchymal transition FAP: Familial adenomatous polyposis GSK-3: Glycogen synthase kinase 3 GSLC: Glioblastoma stem-like cells HDAC: Histone deacetylase HMH: Harmine hydrochloride HPLC: High-performance liquid chromatography HPV: Human papillomavirus HR: Homologous recombination IL-2: Interleukin-2 MAPK: Mitogen-activated protein kinases MMP: Matrix metalloproteinases mTORC1: Mammalian target of rapamycin complex 1 NB: Neuroblastoma NF-B: Nuclear Factor kappa B NHEJ: Nonhomologous end joining NO: Nitric oxide NSCLC: Non-small cell lung cancer PARP: Poly (ADP-ribose) polymerase PI3K: Phosphatidylinositol-3-kinase PTEN: Phosphatase and tensin homolog Raf: Rapidly accelerated fibrosarcoma (Raf) kinase Ras: Rat sarcoma (Ras) protein RK: Extracellular-signal-regulated kinases SAR: Structure-activity relationship SRB: Sulforhodamine B TAZ: Transcriptional coactivator with PDZ-binding motif TCF/LEF: T-cell factor/lymphoid enhancer factor THH: Tetrahydroharmine TLC: Thin layer chromatography TRAP: Telomerase repeated amplification procedure

I., Feito, J., Callaway, J